|Drug Name||Ativan (Lorazepam)|
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|Best Price Per Pill||$3.75|
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Ativan or Lorazepam, is a prescription pharmaceutical belonging to the benzodiazepine class, renowned for its anxiolytic and sedative properties due to its central nervous system depressant effects. As a potent CNS depressant, Ativan is primarily utilized for the management of anxiety disorders, intractable insomnia, and certain refractory seizure disorders. Esteemed for its efficacy and versatility, this medication has garnered widespread prescription rates in the United States and other international medical communities, cementing its status as a prominent therapeutic intervention for various psychological and neurological afflictions. Ativan operates by potentiating the actions of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter crucial in regulating brain activity. The heightened GABA activity induces a soothing influence on the brain, mitigating anxiety and fostering a state of relaxation.
How it Works
Ativan, or lorazepam, belongs to the benzodiazepine class of drugs, acting primarily on the central nervous system to exert its anxiolytic, sedative, and muscle-relaxant effects. The detailed mechanism involves enhancing the activity of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain. Ativan binds to the GABA-A receptors, which are ionotropic chloride channels, potentiating the inhibitory effects of GABA. Upon binding, Ativan facilitates the opening of the chloride channel, allowing an influx of chloride ions. This influx hyperpolarizes the neuron, making it less excitable and reducing the likelihood of action potential generation. As a result, Ativan induces a calming effect on the nervous system, alleviating anxiety and promoting relaxation. However, it’s crucial to use Ativan judiciously due to its potential for tolerance, dependence, and withdrawal symptoms, necessitating careful medical supervision and adherence to prescribed dosages.
Treatment Associated with the Drug
- Anxiety Disorders: Ativan is commonly prescribed to alleviate symptoms associated with various anxiety disorders, such as generalized anxiety disorder (GAD) and panic disorder. It helps reduce excessive worry, nervousness, and restlessness, promoting a sense of calm.
- Insomnia: In cases of short-term insomnia, the drug may be used to facilitate sleep initiation and maintenance due to its sedative effects. However, long-term use is typically avoided to prevent dependence and tolerance.
- Seizures: Lorazepam can be part of the treatment protocol for certain types of seizures, especially in emergencies like status epilepticus. Its anticonvulsant properties aid in controlling and terminating prolonged seizure episodes.
- Preoperative Sedation: At times, healthcare professionals may administer Ativan to patients before surgery to induce sedation and reduce preoperative anxiety.
- Alcohol Withdrawal: During the detoxification process, Ativan can be used to treat anxiety, tremors, and agitation in people who are suffering the effects of alcohol withdrawal.
- Other Medical Conditions: It can also be used in certain cases as an adjunct treatment for conditions such as nausea and vomiting, chemotherapy-induced anticipatory anxiety, and muscle spasms.
Appropriate Prescribed Doses
Below are some general guidelines for the recommended doses of Ativan:
- Anxiety Disorders:
- For adults: The typical starting dosage is 2 to 3 mg per day, divided into two or three doses.
- For elderly or debilitated patients: A lower starting dose of 1 to 2 mg per day is often advised.
- For adults: The starting dose is usually 2 to 4 mg at bedtime.
- The dosage for seizures is typically higher and may range from 2 to 10 mg per day, divided into two to three doses.
- Preoperative Sedation:
- The usual preoperative dose is 2 to 4 mg given 1 to 2 hours before the surgical procedure.
For individuals with liver or kidney impairment, a lower starting dose may be necessary, and adjustments may be made based on the individual’s response to treatment and any adverse effects experienced. The elderly and those with respiratory or respiratory-related conditions may be more sensitive to the sedative effects of Ativan and may require lower doses. Ativan should be administered with caution in individuals with a history of substance abuse or addiction.
Low Prospects Toward Side Effects
Ativan is said to have lower side effects. Some of the usual and rare adverse effects are:
- Coordination problems
- Cognitive impairment
- Memory issues
- Reduced concentration
- Blurred vision
- Gastrointestinal disturbances
- Changes in libido
- Rebound anxiety (with prolonged use)
- Agitation (with prolonged use)
Why Choose Ativan Medication?
Ativan is preferred rather than other anxiety medications because it is particularly effective in providing relief for individuals suffering from anxiety disorders and related symptoms, offering rapid calming effects within 30 to 60 minutes of ingestion. It can be instrumental in managing short-term insomnia when anxiety contributes to sleep disturbances, promoting improved sleep quality during stressful periods. Due to its fast onset, Ativan is sometimes used in emergency situations, such as acute anxiety attacks or severe agitation, to help calm the patient quickly. Moreover, the drug serves as an anticonvulsant, effectively controlling certain types of seizures, especially in life-threatening situations like status epilepticus.
In preoperative settings, Ativan helps alleviate pre-surgery anxiety, allowing patients to experience a more relaxed state before medical procedures. It’s versatility and fast-acting nature also make it suitable for managing acute anxiety attacks or severe agitation during emergency situations. In some cases, Ativan can serve as an adjunctive treatment for depression when anxiety significantly affects an individual’s mental health. Ativan offers a diverse array of formulations, spanning tablets, oral concentrate, and injectable solutions, thereby affording healthcare professionals the discretion to tailor the most appropriate variant to align with the distinctive exigencies and proclivities of individual patients.
Interaction with Other Medicines
Ativan has the possibility to engender potential interactions with various other medicinal agents, thereby precipitating consequences or compromising therapeutic efficacy. Concurrent administration of Ativan with other central nervous system (CNS) depressants, encompassing alcohol, opioids, or concomitant benzodiazepines, may elicit synergistic sedation and respiratory depression. Co-administration with antihistamines, antipsychotics, or skeletal muscle relaxants may potentiate the soporific effects of Ativan, featuring the risk of CNS depression. Ativan’s metabolism also may be modulated when administered with agents influencing hepatic enzymes, such as specific antibiotics or antifungal medications, thereby eliciting altered systemic concentrations of lorazepam.